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Article

The contribution of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: a preliminary study.

The Australian and New Zealand journal of psychiatry - 1 Jan 2012

Quinn Candice R, Dobson-Stone Carol, Outhred Tim, Harris Anthony, Kemp Andrew H

Abstract excerpt

OBJECTIVE: Two reported genetic polymorphisms related to the production of brain-derived neurotrophic factor (BNDF) and reuptake by the serotonin transporter (5-HTT) appear to contribute to depression in combination with stressful life events. The aim of the current study was to investigate the contribution of early life stress (ELS), BDNF (Val versus Met alleles) and 5-HTT polymorphisms (L versus S alleles) to...

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Source

Identifiers

PMID: 22247094
DOI: 10.1177/0004867411430878

Genes

BDNF
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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