The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.

doi:10.1001/archgenpsychiatry.2010.189

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Article

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.

Archives of general psychiatry - 1 May 2011

Karg Katja, Burmeister Margit, Shedden Kerby, Sen Srijan

Abstract excerpt

CONTEXT: Two recent meta-analyses assessed the set of studies exploring the interaction between a serotonin transporter promoter polymorphism (5-HTTLPR) and stress in the development of depression and concluded that the evidence did not support the presence of the interaction. However, even the l...

Topics

Adult
Alleles
Child
Child Abuse
Depressive Disorder
Gene Expression
Genetic Carrier Screening
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Life Change Events
Phenotype
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins
Social Environment

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Identifiers

PMID: 21199959
DOI: 10.1001/archgenpsychiatry.2010.189
PMCID: PMC3740203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21199959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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