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Article

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.

Psychological medicine - 1 Jan 2005

Gillespie Nathan A, Whitfield John B, Williams Ben, Heath Andrew C, Martin Nicholas G

Abstract excerpt

BACKGROUND: Serotonin is a good candidate for major depression. We attempted to replicate the study by Caspi and colleagues [Science (2003) 301, 386-389] which reported a significant interaction between serotonin transporter (5-HTTLPR) genotype and stressful life events when predicting major depression. METHOD: We typed the serotonin promoter 5-HTTLPR gene in 1206 male and female twins aged 19-78 years (mean =...

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Identifiers

PMID: 15842033
DOI: 10.1017/s0033291704002727

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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