Article
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.
Psychological medicine - 1 Jan 2005
Gillespie Nathan A, Whitfield John B, Williams Ben, Heath Andrew C, Martin Nicholas G
Abstract excerpt
BACKGROUND: Serotonin is a good candidate for major depression. We attempted to replicate the study by Caspi and colleagues [Science (2003) 301, 386-389] which reported a significant interaction between serotonin transporter (5-HTTLPR) genotype and stressful life events when predicting major depression. METHOD: We typed the serotonin promoter 5-HTTLPR gene in 1206 male and female twins aged 19-78 years (mean =...
Topics
- Aged
- Depressive Disorder, Major
- Diagnostic and Statistical Manual of Mental Disorders
- Female
- Genotype
- Humans
- Interview, Psychological
- Life Change Events
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Middle Aged
- Nerve Tissue Proteins
- Regression Analysis