Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

PloS one - 1 Jan 2012

Hirner Heidrun, Günes Cagatay, Bischof Joachim, Wolff Sonja, Grothey Arnhild, Kühl Marion, Oswald Franz, Wegwitz Florian, Bösl Michael R, Trauzold Anna, Henne-Bruns Doris, Peifer Christian, Leithäuser Frank, Deppert Wolfgang, Knippschild Uwe

Abstract excerpt

Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transforming activity of SV40, including the transforming activity of T-Ag, the major transforming protein of SV40, itself. Here we characterized the effects of mutant CK1δ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral, Tumor
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

Share to Mice, Inbred BALB C

Share to Milk Proteins

Share to Simian virus 40

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 22235331
DOI: 10.1371/journal.pone.0029709
PMCID: PMC3250488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.PMID 22235331Read ↗

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.Semantic proximity Read ↗

Therapeutic targeting of casein kinase 1δ in breast cancerSemantic proximity Read ↗

Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.Semantic proximity Read ↗

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.Semantic proximity Read ↗

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.Semantic proximity Read ↗

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivoSemantic proximity Read ↗

CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.Semantic proximity Read ↗

Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40.Semantic proximity Read ↗

Generation of protein kinase Ck1alpha mutants which discriminate between canonical and non-canonical substrates.Semantic proximity Read ↗

Atypical Protein Kinase Cι Is Required for Bronchioalveolar Stem Cell Expansion and Lung TumorigenesisSemantic proximity Read ↗

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.Semantic proximity Read ↗

Tnk1/Kos1 knockout mice develop spontaneous tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.