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Article

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

International journal of cancer - 15 Jun 2015

Richter Julia, Ullah Kalim, Xu Pengfei, Alscher Vanessa, Blatz Annette, Peifer Christian, Halekotte Jakob, Leban Johann, Vitt Daniel, Holzmann Karlheinz, Bakulev Vasiliy, Pinna Lorenzo A, Henne-Bruns Doris, Hillenbrand Andreas, Kornmann Marko, Leithäuser Frank, Bischof Joachim, Knippschild Uwe

Abstract excerpt

Colorectal cancer (CRC) is the fourth leading cause of cancer related death worldwide due to high apoptotic resistance and metastatic potential. Because mutations as well as deregulation of CK1 isoforms contribute to tumor development and tumor progression, CK1 has become an interesting drug target. In this study we show that CK1 isoforms are differently expressed in colon tumor cell lines and that growth of...

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Identifiers

PMID: 25404202
DOI: 10.1002/ijc.29346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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