Article
Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.
Breast cancer research : BCR - 1 Jan 2010
Foldynová-Trantírková Silvie, Sekyrová Petra, Tmejová Katerina, Brumovská Eva, Bernatík Ondrej, Blankenfeldt Wulf, Krejcí Pavel, Kozubík Alois, Dolezal Tomás, Trantírek Lukás, Bryja Vítezslav
Abstract excerpt
INTRODUCTION: Breast cancer is one of the most common types of cancer in women. One of the genes that were found mutated in breast cancer is casein kinase 1 epsilon (CK1epsilon). Because CK1epsilon is a crucial regulator of the Wnt signaling cascades, we determined how these CK1epsilon mutations interfere with the Wnt pathway and affect the behavior of epithelial breast cancer cell lines. METHODS: We performed in...
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