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Article

Therapeutic targeting of casein kinase 1δ in breast cancer

16 Dec 2015

Abstract excerpt

Identification of specific drivers of human cancer is required to instruct the development of targeted therapeutics. We demonstrate that CSNK1D is amplified and/or overexpressed in human breast tumors and that casein kinase 1δ (CK1δ) is a vulnerability of human breast cancer subtypes overexpressing this kinase. Specifically, selective knockdown of CK1δ, or treatment with a highly selective and potent CK1δ...

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PMID: 26676609
DOI: 10.1126/scitranslmed.aac8773

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