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Article

Tnk1/Kos1 knockout mice develop spontaneous tumors.

Cancer research - 1 Nov 2008

Hoare Sarasija, Hoare Kishalay, Reinhard Mary K, Lee Young J, Oh S Paul, May W Stratford

Abstract excerpt

Tnk1/Kos1 is a non-receptor protein tyrosine kinase implicated in negatively regulating cell growth in a mechanism requiring its intrinsic catalytic activity. Tnk1/Kos1 null mice were created by homologous recombination by deleting the catalytic domain. Both Tnk1(+/-) and Tnk1(-/-) mice develop spontaneous tumors, including lymphomas and carcinomas, at high rates [27% (14 of 52) and 43% (12 of 28), respectively]....

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Source

Identifiers

PMID: 18974114
DOI: 10.1158/0008-5472.CAN-08-1467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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