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Article

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.

Molecular and cellular biology - 1 Dec 2002

Piva Roberto, Liu Jian, Chiarle Roberto, Podda Antonello, Pagano Michele, Inghirami Giorgio

Abstract excerpt

Skp1 is involved in a variety of crucial cellular functions, among which the best understood is the formation together with Cul1 of Skp1-cullin-F-box protein ubiquitin ligases. To investigate the role of Skp1, we generated transgenic (Tg) mice expressing a Cul1 deletion mutant (Cul1-N252) able to...

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Identifiers

PMID: 12417738
DOI: 10.1128/MCB.22.23.8375-8387.2002
PMCID: PMC134052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12417738-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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