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Article

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Cancer research - 15 Mar 2011

Symonds Jennifer M, Ohm Angela M, Carter Cristan J, Heasley Lynn E, Boyle Theresa A, Franklin Wilbur A, Reyland Mary E

Abstract excerpt

Oncogenic activation of K-ras occurs commonly in non-small cell lung cancer (NSCLC), but strategies to therapeutically target this pathway have been challenging to develop. Information about downstream effectors of K-ras remains incomplete, and tractable targets are yet to be defined. In this study, we investigated the role of protein kinase C δ (PKCδ) in K-ras-dependent lung tumorigenesis by using a mouse...

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Immunoblotting
Mice, Nude
Mitogen-Activated Protein Kinases
Protein Kinase C-delta
ras Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Interference

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Identifiers

PMID: 21335545
DOI: 10.1158/0008-5472.CAN-10-1511
PMCID: PMC3271733

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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