Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo

3 Jun 2013

Abstract excerpt

The vaccinia-related kinases (VRKs) comprise a branch of the casein kinase family. VRK1, a ser/thr kinase with a nuclear localization, is the most well-studied paralog and has been described as a proproliferative protein. In lower eukaryotes, a loss of VRK1 activity is associated with severe mitotic and meiotic defects. Mice that are hypomorphic for VRK1 expression are infertile, and depletion of VRK1 in tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Nuclear Structure and Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23732708
DOI: 10.1038/oncsis.2013.11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivoPMID 23732708Read ↗

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage responseSemantic proximity Read ↗

Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell ProliferationSemantic proximity Read ↗

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.Semantic proximity Read ↗

p53 Stabilization and Accumulation Induced by Human Vaccinia-Related Kinase 1Semantic proximity Read ↗

Vaccinia-related kinase 1 is required for early uterine development in Caenorhabditis elegans.Semantic proximity Read ↗

VRK1 phosphorylates CREB and mediates <i>CCND1</i> expressionSemantic proximity Read ↗

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian CancerSemantic proximity Read ↗

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.Semantic proximity Read ↗

Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2Semantic proximity Read ↗

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.Semantic proximity Read ↗

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancerSemantic proximity Read ↗

Plk1 overexpression induces chromosomal instability and suppresses tumor developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.