Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

doi:10.1007/s11357-011-9373-7

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Article

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Age (Dordrecht, Netherlands) - 1 Apr 2013

Soerensen Mette, Dato Serena, Tan Qihua, Thinggaard Mikael, Kleindorp Rabea, Beekman Marian, Suchiman H Eka D, Jacobsen Rune, McGue Matt, Stevnsner Tinna, Bohr Vilhelm A, de Craen Anton J M, Westendorp Rudi G J, Schreiber Stefan, Slagboom P Eline, Nebel Almut, Vaupel James W, Christensen Kaare, Christiansen Lene

Abstract excerpt

In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; TGFB1; APOA4; APOC3; SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. In a case-control study of 1,089 oldest-old (ages 92-93) and 736 middle-aged Danes, the minor allele frequency (MAF) of rs769449 (APOE)...

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Identifiers

PMID: 22234866
DOI: 10.1007/s11357-011-9373-7
PMCID: PMC3592963

Genes

APOE
CETP
HSPA14
MAF
ACE
APOA4
APOC3
HFE
MTHFR
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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