Article
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.
Mechanisms of ageing and development - 1 Jan 2000
Nebel Almut, Kleindorp Rabea, Caliebe Amke, Nothnagel Michael, Blanché Hélène, Junge Olaf, Wittig Michael, Ellinghaus David, Flachsbart Friederike, Wichmann Heinz-Erich, Meitinger Thomas, Nikolaus Susanna, Franke Andre, Krawczak Michael, Lathrop Mark, Schreiber Stefan
Abstract excerpt
We conducted a case-control genome-wide association study (GWAS) of human longevity, comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 years) and 1085 controls (mean age: 60.2 years) from Germany. Only one association, namely that of SNP rs4420638 near the APOC1 gene, achieved genome-wide significance (allele-based P=1.8×10(-10)). However, logistic regression analysis revealed...
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