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Article

SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer

10 Aug 2021

Abstract excerpt

BACKGROUNDImmune checkpoint inhibitors (ICIs) fail to demonstrate efficacy in pancreatic cancer. Recently, genomic biomarkers have been associated with response to ICIs: microsatellite instability high (MSI-H) and tumor mutation burden (TMB) > 10 mutations/Mb. Alterations in Switch/Sucrose Nonfermentable (SWI/SNF) chromatin remodeling genes may predispose to improved outcomes with immunotherapy. The current study...

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PMID: 34375311
DOI: 10.1172/jci.insight.150453

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