Article
Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population.
Molecular carcinogenesis - 1 Sept 2015
Zhu Beibei, Tian Jing, Zhong Rong, Tian Yao, Chen Wei, Qian Jiaming, Zou Li, Xiao Min, Shen Na, Yang Hong, Lou Jiao, Qiu Qian, Ke Juntao, Lu Xinghua, Song Wei, Li Hui, Liu Li, Wang Li, Miao Xiaoping
Abstract excerpt
Pancreatic cancer (PC) is an aggressive malignancy with extremely low 5-year survival rate (<5%). SWItch/Sucrose Non Fermentable (SWI/SNF) complex is a core factor for chromatin-remodeling that utilize energy of ATP hydrolysis to mobilize nucleosomes, and modulate gene transcription. Recent studies have identified recurrent mutations in major components of SWI/SNF in a variety of human cancers, including PC. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.