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Article

Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel.

FEBS letters - 25 Aug 2014

Li Qingxin, Ng Hui Qi, Yoon Ho Sup, Kang CongBao

Abstract excerpt

The gating of the hERG channel is regulated by its eag domain through molecular interaction with either the cyclic nucleotide-binding homology domain (CNBHD) or the linker between transmembrane segments 4 and 5. Our NMR study on the purified CNBHD demonstrated that it contains nine β-strands and does not bind cAMP. We show that the eag domain binds to the CBND through an interface containing several...

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Identifiers

PMID: 24931372
DOI: 10.1016/j.febslet.2014.05.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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