Structural properties of PAS domains from the KCNH potassium channels.

doi:10.1371/journal.pone.0059265

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Article

Structural properties of PAS domains from the KCNH potassium channels.

PloS one - 1 Jan 2013

Adaixo Ricardo, Harley Carol A, Castro-Rodrigues Artur F, Morais-Cabral João H

Abstract excerpt

KCNH channels form an important family of voltage gated potassium channels. These channels include a N-terminal Per-Arnt-Sim (PAS) domain with unknown function. In other proteins PAS domains are implicated in cellular responses to environmental queues through small molecule binding or involvement in signaling cascades. To better understand their role we characterized the structural properties of several channel...

Topics

Animals
Binding Sites
Crystallography, X-Ray
Drosophila Proteins
Drosophila melanogaster
Ether-A-Go-Go Potassium Channels
Humans
Hydrophobic and Hydrophilic Interactions
Mice
Models, Molecular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Potassium Channels

Protein Binding

Protein Structure, Secondary

Protein Structure, Tertiary

Recombinant Proteins

Static Electricity

Structure-Activity Relationship

Source

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Identifiers

PMID: 23555008
DOI: 10.1371/journal.pone.0059265
PMCID: PMC3598652

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