Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.

Blood reviews - 1 Mar 2011

Paganin Maddalena, Ferrando Adolfo

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting from the malignant transformation of immature T-cell progenitors. Originally associated with a dismal prognosis, the outcome of T-ALL patients has improved remarkably over the last two decades as a result of the introduction of intensified chemotherapy protocols. However, these treatments are associated with significant acute...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Gene Expression Regulation, Leukemic

Share to NOTCH1 gene

Share to Mutation

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Source

Open in PubMed Open full text

Identifiers

PMID: 20965628
DOI: 10.1016/j.blre.2010.09.004
PMCID: PMC3033461

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.PMID 20965628Read ↗

Notch signaling in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

[Research advance on the pathogenesis of T-ALL induced by notch 1 activating mutations].Semantic proximity Read ↗

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Recent Advances in the Biology and Treatment of T Cell Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Friend or foe: can activating mutations in NOTCH1 contribute to a favorable treatment outcome in patients with T-ALL?Semantic proximity Read ↗

MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategiesSemantic proximity Read ↗

Recent advances on NOTCH signaling in T-ALL.Semantic proximity Read ↗

The Physiopathology of T- Cell Acute Lymphoblastic Leukemia: Focus on Molecular AspectsSemantic proximity Read ↗

T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies.Semantic proximity Read ↗

Notch signaling as a therapeutic target for acute lymphoblastic leukemiaSemantic proximity Read ↗

Notch Partners in the Long Journey of T-ALL Pathogenesis.Semantic proximity Read ↗

The role of NOTCH1 signaling in T-ALL.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.