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Article

T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements.

Leukemia research - 1 Apr 2010

Mansur Marcela Braga, Emerenciano Mariana, Splendore Alessandra, Brewer Lilian, Hassan Rocio, Pombo-de-Oliveira Maria S

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) may affect children in very early age. However, the critical events leading to this brief latency is still unclear. We used standard methods to explore NOTCH1 mutations and other specific molecular markers in 15 early childhood T-ALL cases. Most of them consisted of immature differentiation subtype. Despite being found in a lower frequency than that described for...

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Share to Cell Transformation, Neoplastic
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

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Share to Histone-Lysine N-Methyltransferase

Share to Myeloid-Lymphoid Leukemia Protein

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Source

Identifiers

PMID: 19631984
DOI: 10.1016/j.leukres.2009.06.026

Genes

NOTCH1
FLT3
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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