Article
T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements.
Leukemia research - 1 Apr 2010
Mansur Marcela Braga, Emerenciano Mariana, Splendore Alessandra, Brewer Lilian, Hassan Rocio, Pombo-de-Oliveira Maria S
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) may affect children in very early age. However, the critical events leading to this brief latency is still unclear. We used standard methods to explore NOTCH1 mutations and other specific molecular markers in 15 early childhood T-ALL cases. Most of them consisted of immature differentiation subtype. Despite being found in a lower frequency than that described for...
Topics
- Cell Transformation, Neoplastic
- Child, Preschool
- Chromosome Aberrations
- Female
- Gene Rearrangement
- Genes, T-Cell Receptor delta
- Genes, T-Cell Receptor gamma
- Genetic Testing
- Histone-Lysine N-Methyltransferase
- Humans
- Infant
- Male
- Mutation
- Myeloid-Lymphoid Leukemia Protein