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Article

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

The EMBO journal - 4 Aug 2004

Høiby Torill, Mitsiou Dimitra J, Zhou Huiqing, Erdjument-Bromage Hediye, Tempst Paul, Stunnenberg Hendrik G

Abstract excerpt

The transcription factor TFIIA is encoded by two genes, TFIIAalphabeta and TFIIAgamma. In higher eukaryotes, the TFIIAalphabeta is translated as a precursor and undergoes proteolytic cleavage; the regulation and biological implications of the cleavage have remained elusive. We determined by Edman degradation that the TFIIAbeta subunit starts at Asp 278. We found that a cleavage recognition site (CRS), a string of...

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Identifiers

PMID: 15257296
DOI: 10.1038/sj.emboj.7600304
PMCID: PMC514921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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