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Article

Structure-function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement.

Nucleic acids research - 1 Feb 2008

Naji Souad, Bertero Michela G, Spitalny Patrizia, Cramer Patrick, Thomm Michael

Abstract excerpt

The active center clefts of RNA polymerase (RNAP) from the archaeon Pyrococcus furiosus (Pfu) and of yeast RNAP II are nearly identical, including four protruding loops, the lid, rudder, fork 1 and fork 2. Here we present a structure-function analysis of recombinant Pfu RNAP variants lacking thes...

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Identifiers

PMID: 18073196
DOI: 10.1093/nar/gkm1086
PMCID: PMC2241882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18073196-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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