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Article

Transcription factor ISX mediates the cross talk between diet and immunity.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2017

Widjaja-Adhi Made Airanthi K, Palczewski Grzegorz, Dale Kali, Knauss Elizabeth A, Kelly Mary E, Golczak Marcin, Levine Alan D, von Lintig Johannes

Abstract excerpt

The intestinal epithelium is a major site for the conversion of dietary β-carotene to retinaldehyde by the enzyme BCO1. The majority of retinaldehyde is further metabolized to retinol (vitamin A), esterified and packaged into triacylglycerol-rich chylomicrons for bodily distribution. Some serve on-site for the synthesis of retinoic acid, a hormone-like compound, which exerts pleiotropic and dominant effects on...

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Source

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Identifiers

PMID: 29073082
DOI: 10.1073/pnas.1714963114
PMCID: PMC5664558

Genes

ISX
BCO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Transcription factor ISX mediates the cross talk between diet and immunity.PMID 29073082Read ↗

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.Semantic proximity Read ↗

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasisSemantic proximity Read ↗

Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.Semantic proximity Read ↗

Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1).Semantic proximity Read ↗

Interaction Between Retinol Intake and ISX rs5755368 Polymorphism in Colorectal Cancer Risk: A Case-control Study Among the Korean PopulationSemantic proximity Read ↗

Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid researchSemantic proximity Read ↗

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitisSemantic proximity Read ↗

Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case-control study in a Korean population.Semantic proximity Read ↗

Retinoic Acid as a Modulator of T Cell ImmunitySemantic proximity Read ↗

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