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Article

Intestinal bacteria condition dendritic cells to promote IgA production.

PloS one - 2 Jul 2008

Massacand Joanna C, Kaiser Patrick, Ernst Bettina, Tardivel Aubry, Bürki Kurt, Schneider Pascal, Harris Nicola L

Abstract excerpt

Immunoglobulin (Ig) A represents the predominant antibody isotype produced at the intestinal mucosa, where it plays an important role in limiting the penetration of commensal intestinal bacteria and opportunistic pathogens. We show in mice that Peyer's Patch-derived dendritic cells (PP-DC) exhibit a specialized phenotype allowing the promotion of IgA production by B2 cells. This phenotype included increased...

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Identifiers

PMID: 18596964
DOI: 10.1371/journal.pone.0002588
PMCID: PMC2432026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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