Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Cell metabolism - 1 May 2006

Sun Yuxiang, Asnicar Mark, Saha Pradip K, Chan Lawrence, Smith Roy G

Abstract excerpt

Ghrelin and leptin are suggested to regulate energy homeostasis as mutual antagonists on hypothalamic neurons that regulate feeding behavior. We employed reverse genetics to investigate the interplay between ghrelin and leptin. Leptin-deficient mice (ob/ob) are hyperphagic, obese, and hyperglycem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature Regulation
Share to Ghrelin
Share to Ion Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leptin

Share to Mice, Obese

Share to Pancreas

Share to Peptide Hormones

Share to Uncoupling Protein 2

Source

Identifiers

PMID: 16679295
DOI: 10.1016/j.cmet.2006.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16679295-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.PMID 16679295Read ↗

Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background.Semantic proximity Read ↗

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis.Semantic proximity Read ↗

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesitySemantic proximity Read ↗

Cellular and molecular basis of leptin resistanceSemantic proximity Read ↗

Mice lacking ghrelin receptors resist the development of diet-induced obesity.Semantic proximity Read ↗

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.Semantic proximity Read ↗

Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding.Semantic proximity Read ↗

Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish.Semantic proximity Read ↗

Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.Semantic proximity Read ↗

The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity.Semantic proximity Read ↗

Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance.Semantic proximity Read ↗

IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.