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Article

iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling.

Biochimica et biophysica acta - 1 May 2016

Deng Xiuling, Wang Jiliang, Jiao Li, Utaipan Tanyarath, Tuma-Kellner Sabine, Schmitz Gerd, Liebisch Gerhard, Stremmel Wolfgang, Chamulitrat Walee

Abstract excerpt

PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2β is known to play a house-keeping role in phospholipid metabolism and remodeling. However, its role in NAFLD pathogenesis has not been supported by results obtained from high-fat feeding of iPLA2β-null (PKO) mice. Unlike livers of human NAFLD and...

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PMID: 26873633
DOI: 10.1016/j.bbalip.2016.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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