Article
Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy.
The Journal of physiology - 1 Jun 2005
Minhas Khalid M, Khan Shakil A, Raju Shubha V Y, Phan Alexander C, Gonzalez Daniel R, Skaf Mike W, Lee Kwangho, Tejani Ankit D, Saliaris Anastasios P, Saliaris Anastasies P, Barouch Lili A, O'Donnell Christopher P, Emala Charles W, Berkowitz Dan E, Hare Joshua M
Abstract excerpt
Impaired leptin signalling in obesity is increasingly implicated in cardiovascular pathophysiology. To explore mechanisms for leptin activity in the heart, we hypothesized that physiological leptin signalling participates in maintaining cardiac beta-adrenergic regulation of excitation-contraction coupling. We studied 10-week-old (before development of cardiac hypertrophy) leptin-deficient (ob/ob, n=12) and...
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