Article
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.
Scientific reports - 13 Jan 2017
Chung Youn Wook, Ahmad Faiyaz, Tang Yan, Hockman Steven C, Kee Hyun Jung, Berger Karin, Guirguis Emilia, Choi Young Hun, Schimel Dan M, Aponte Angel M, Park Sunhee, Degerman Eva, Manganiello Vincent C
Abstract excerpt
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated...
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