Article
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity.
PLoS biology - 1 May 2018
Zhang Shengjie, Cao Hongchao, Li Yan, Jing Yanyan, Liu Shengnan, Ye Cheng, Wang Hui, Yu Shuxian, Peng Chengyuan, Hui Lijian, Wang Yu-Cheng, Zhang Haibing, Guo Feifan, Zhai Qiwei, Wang Hui, Huang Ruimin, Zhang Ling, Jiang Jingjing, Liu Wei, Ying Hao
Abstract excerpt
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocytes, which positively regulate the transcription of uncoupling protein 1 (UCP-1). However, the physiological role of p38 in adipose tissues, especially the white adipose tissue (WAT), is largely unknown. Here, we show that mice lacking p38α in adipose tissues display a lean phenotype, improved metabolism, and...
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