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Article

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis.

Endocrinology - 1 Apr 2014

D'souza Anna M, Asadi Ali, Johnson James D, Covey Scott D, Kieffer Timothy J

Abstract excerpt

Leptin, an adipocyte-derived hormone, has well-established anorexigenic effects but is also able to regulate glucose homeostasis independent of body weight. Until recently, the ob/ob mouse was the only animal model of global leptin deficiency. Here we report the effects of leptin deficiency on glucose homeostasis in male and female leptin knockout (KO) rats. Leptin KO rats developed obesity by 6 to 7 weeks of...

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Identifiers

PMID: 24467741
DOI: 10.1210/en.2013-1523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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