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Article

Transgenic expression of a mutated cyclin-dependent kinase 4 (CDK4/R24C) in pancreatic beta-cells prevents progression of diabetes in db/db mice.

Diabetes research and clinical practice - 1 Oct 2008

Miyawaki Katsuyuki, Inoue Hiroshi, Keshavarz Parvaneh, Mizuta Kuniko, Sato Aya, Sakamoto Yukiko, Moritani Maki, Kunika Kiyoshi, Tanahashi Toshihito, Itakura Mitsuo

Abstract excerpt

In an attempt to rectify the hyperglycemic state in obese insulin resistant db/db mice, a transgenic line was generated (db/db-CDK4(R24C)) that expresses a constitutively active form of cyclin-dependent kinase 4 (CDK4/R24C) under the control of the insulin promoter. Compared with non-transgenic db/db littermates, adult db/db-CDK4(R24C) mice show near-complete glycemic normalization and improved plasma lipid...

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PMID: 18678431
DOI: 10.1016/j.diabres.2008.06.014

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CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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