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Article

ZBTB1 is a determinant of lymphoid development.

The Journal of experimental medicine - 16 Jan 2012

Siggs Owen M, Li Xiaohong, Xia Yu, Beutler Bruce

Abstract excerpt

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain...

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Share to Hematopoietic Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C3H

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Source

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Identifiers

PMID: 22201126
DOI: 10.1084/jem.20112084
PMCID: PMC3260866

Genes

ZBTB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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