Article
Heritable T-cell malignancy models established in a zebrafish phenotypic screen.
Leukemia - 1 Oct 2009
Frazer J K, Meeker N D, Rudner L, Bradley D F, Smith A C H, Demarest B, Joshi D, Locke E E, Hutchinson S A, Tripp S, Perkins S L, Trede N S
Abstract excerpt
T-cell neoplasias are common in pediatric oncology, and include acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LBL). These cancers have worse prognoses than their B-cell counterparts, and their treatments carry significant morbidity. Although many pediatric malignancies have characteristic translocations, most T-lymphocyte-derived diseases lack cytogenetic hallmarks. Lacking these informative...
Topics
- Animals
- Animals, Genetically Modified
- Disease Models, Animal
- Flow Cytometry
- Genetic Predisposition to Disease
- Green Fluorescent Proteins
- Humans
- Immunoenzyme Techniques
- Incidence
- Mutagenesis
- Phenotype
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- RNA, Messenger