Article
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Haematologica - 1 Mar 2017
Scheijen Blanca, Boer Judith M, Marke René, Tijchon Esther, van Ingen Schenau Dorette, Waanders Esmé, van Emst Liesbeth, van der Meer Laurens T, Pieters Rob, Escherich Gabriele, Horstmann Martin A, Sonneveld Edwin, Venn Nicola, Sutton Rosemary, Dalla-Pozza Luciano, Kuiper Roland P, Hoogerbrugge Peter M, den Boer Monique L, van Leeuwen Frank N
Abstract excerpt
Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis. In a large discovery cohort of 533 childhood B-cell precursor acute lymphoblastic leukemia patients, we observed...
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