Article
Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish.
Open biology - 1 Jul 2018
Chi Yali, Huang Zhibin, Chen Qi, Xiong Xiaojie, Chen Kemin, Xu Jin, Zhang Yiyue, Zhang Wenqing
Abstract excerpt
Transcription factor RUNX1 holds an integral role in multiple-lineage haematopoiesis and is implicated as a cofactor in V(D)J rearrangements during lymphocyte development. Runx1 deficiencies resulted in immaturity and reduction of lymphocytes in mice. In this study, we found that runx1W84X/W84X mutation led to the reduction and disordering of B cells, as well as the failure of V(D)J rearrangements in B cells but...
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