Article
Frequent mutations in the mitochondrial control region DNA in breast tissue.
Cancer letters - 8 Nov 2004
Rosson Dan, Keshgegian Albert A
Abstract excerpt
It has been suggested that the extent of mitochondrial DNA mutations might be useful in the prognosis of cancer outcome and/or the response to certain therapies. In order to investigate whether a high incidence of mutations exists in mitochondrial DNA of breast cancer tissues, we screened three regions of the mitochondrial genome by PCR amplification followed by DNA sequence analysis. Laser capture...
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