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Article

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer.

Journal of translational medicine - 5 Oct 2023

Li Yanni, Sundquist Kristina, Vats Sakshi, Hong Mun-Gwan, Wang Xiao, Chen Yilun, Hedelius Anna, Saal Lao H, Sundquist Jan, Memon Ashfaque A

Abstract excerpt

BACKGROUND: Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially alternative to identify potential missing cancer information in circulation at an early stage. METHODS: To...

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Identifiers

PMID: 37798736
DOI: 10.1186/s12967-023-04534-4
PMCID: PMC10557196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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