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Article

Cardioprotection by Hepc1 in cTnT(R141W) transgenic mice.

Transgenic research - 1 Aug 2012

Zhang Li, Lu Dan, Zhang Wei, Quan Xiongzhi, Dong Wei, Xu Yanfeng, Zhang Lianfeng

Abstract excerpt

Hepcidin 1 (Hepc1) is a peptide hormone secreted by the liver in response to iron loading. It is expressed in the heart and is thought to play a role in the regulation of iron homeostasis in an autocrine and paracrine fashion. We have shown that expression of Hepc1 is strongly down-regulated in the heart of the cTnT(R141W) transgenic mouse model of dilated cardiomyopathy (DCM) at 3 months of age. Transgenic mice...

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Identifiers

PMID: 22198484
DOI: 10.1007/s11248-011-9582-y

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