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Article

Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis.

Journal of hypertension - 1 Apr 2018

Podesser Bruno K, Kreibich Maximilian, Dzilic Elda, Santer David, Förster Lorenz, Trojanek Sandra, Abraham Dietmar, Krššák Martin, Klein Klaus U, Tretter Eva V, Kaun Christoph, Wojta Johann, Kapeller Barbara, Gonçalves Inês Fonseca, Trescher Karola, Kiss Attila

Abstract excerpt

AIMS: Left ventricular (LV) hypertrophy is characterized by cardiomyocyte hypertrophy and interstitial fibrosis ultimately leading to increased myocardial stiffness and reduced contractility. There is substantial evidence that the altered expression of matrix metalloproteinases (MMP) and Tenascin-C (TN-C) are associated with the progression of adverse LV remodeling. However, the role of TN-C in the development of...

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PMID: 29283973
DOI: 10.1097/HJH.0000000000001628

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