Article
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.
Circulation research - 20 Jul 2001
Yet S F, Tian R, Layne M D, Wang Z Y, Maemura K, Solovyeva M, Ith B, Melo L G, Zhang L, Ingwall J S, Dzau V J, Lee M E, Perrella M A
Abstract excerpt
Heme oxygenase (HO)-1 degrades the pro-oxidant heme and generates carbon monoxide and antioxidant bilirubin. We have previously shown that in response to hypoxia, HO-1-null mice develop infarcts in the right ventricle of their hearts and that their cardiomyocytes are damaged by oxidative stress. To test whether HO-1 protects against oxidative injury in the heart, we generated cardiac-specific transgenic mice...
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