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Article

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004

Shohet Ralph V, Kisanuki Yaz Y, Zhao Xiao-Song, Siddiquee Zakir, Franco Fatima, Yanagisawa Masashi

Abstract excerpt

Endothelin 1 (ET-1), a potent vasoconstrictor peptide expressed by endothelium, is also produced in the heart in response to a variety of stresses. It induces hypertrophy in cultured cardiac myocytes but only at concentrations far greater than those found in plasma. We tested whether ET-1 generat...

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Identifiers

PMID: 14764893
DOI: 10.1073/pnas.0307159101
PMCID: PMC357056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14764893-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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