Article
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.
PLoS pathogens - 1 Dec 2011
Olivieri Anna, Collins Christine R, Hackett Fiona, Withers-Martinez Chrislaine, Marshall Joshua, Flynn Helen R, Skehel J Mark, Blackman Michael J
Abstract excerpt
The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membrane antigen-1 (AMA1) is a merozoite protein that plays a critical role in invasion. Antibodies against AMA1 prevent invasion and can protect against malaria in vivo, so AMA1 is of interest as a malaria vaccine candidate....
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