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Article

Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

Parussini Fabiola, Tang Qing, Moin Syed M, Mital Jeffrey, Urban Sinisa, Ward Gary E

Abstract excerpt

Apical membrane antigen 1 (AMA1) is a conserved transmembrane adhesin of apicomplexan parasites that plays an important role in host-cell invasion. Toxoplasma gondii AMA1 (TgAMA1) is secreted onto the parasite surface and subsequently released by proteolytic cleavage within its transmembrane domain. To elucidate the function of TgAMA1 intramembrane proteolysis, we used a heterologous cleavage assay to...

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Identifiers

PMID: 22523242
DOI: 10.1073/pnas.1114661109
PMCID: PMC3358886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.PMID 22523242Read ↗

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