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Article

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.

The Journal of cell biology - 25 Sept 2006

O'Donnell Rebecca A, Hackett Fiona, Howell Steven A, Treeck Moritz, Struck Nicole, Krnajski Zita, Withers-Martinez Chrislaine, Gilberger Tim W, Blackman Michael J

Abstract excerpt

Apicomplexan pathogens are obligate intracellular parasites. To enter cells, they must bind with high affinity to host cell receptors and then uncouple these interactions to complete invasion. Merozoites of Plasmodium falciparum, the parasite responsible for the most dangerous form of malaria, invade erythrocytes using a family of adhesins called Duffy binding ligand-erythrocyte binding proteins (DBL-EBPs). The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17000879
DOI: 10.1083/jcb.200604136
PMCID: PMC2064393

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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