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Article

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

22 Jul 2005

Abstract excerpt

Apical membrane antigen-1 (AMA1) is a conserved apicomplexan protein that plays an important but undefined role in host cell invasion. We have studied the fate of Plasmodium falciparum AMA1 (PfAMA1) during erythrocyte invasion by the malaria merozoite, and compared it with that of the Toxoplasma gondii orthologue, TgAMA1. Shedding of the PfAMA1 ectodomain goes essentially to completion during invasion, and occurs...

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Identifiers

PMID: 16102004
DOI: 10.1111/j.1365-2958.2005.04772.x

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Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogensPMID 16102004Read ↗

Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.Semantic proximity Read ↗

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Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasionSemantic proximity Read ↗

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A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by <i>Toxoplasma</i>Semantic proximity Read ↗

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.Semantic proximity Read ↗

Conditional Expression of <i>Toxoplasma gondii</i> Apical Membrane Antigen-1 (TgAMA1) Demonstrates That TgAMA1 Plays a Critical Role in Host Cell InvasionSemantic proximity Read ↗

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Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasionSemantic proximity Read ↗

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