Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory Antibody

18 Apr 2006

Abstract excerpt

Apical membrane antigen 1 (AMA1) is currently one of the leading malarial vaccine candidates. Anti-AMA1 antibodies can inhibit the invasion of erythrocytes by Plasmodium merozoites and prevent the multiplication of blood-stage parasites. Here we describe an anti-AMA1 monoclonal antibody (MAb 1F9) that inhibits the invasion of Plasmodium falciparum parasites in vitro. We show that both reactivity of MAb 1F9 with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Invertebrate Immune Response Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16622199
DOI: 10.1128/iai.74.5.2628-2636.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory AntibodyPMID 16622199Read ↗

Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory AntibodySemantic proximity Read ↗

Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.Semantic proximity Read ↗

Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum.Semantic proximity Read ↗

Alanine Mutagenesis of the Primary Antigenic Escape Residue Cluster, C1, of Apical Membrane Antigen 1Semantic proximity Read ↗

Structure of AMA1 from <i>Plasmodium falciparum</i> reveals a clustering of polymorphisms that surround a conserved hydrophobic pocketSemantic proximity Read ↗

Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.Semantic proximity Read ↗

Allele specificity of naturally acquired antibody responses against Plasmodium falciparum apical membrane antigen 1.Semantic proximity Read ↗

Overcoming Antigenic Diversity by Enhancing the Immunogenicity of Conserved Epitopes on the Malaria Vaccine Candidate Apical Membrane Antigen-1Semantic proximity Read ↗

Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides.Semantic proximity Read ↗

Phage-displayed Peptides Bind to the Malarial Protein Apical Membrane Antigen-1 and Inhibit the Merozoite Invasion of Host ErythrocytesSemantic proximity Read ↗

Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response.Semantic proximity Read ↗

Specificity of the Protective Antibody Response to Apical Membrane Antigen 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.