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The Disulfide Bond Structure of Plasmodium Apical Membrane Antigen-1

1 Nov 1996

Abstract excerpt

Apical membrane antigen-1 (AMA-1) of Plasmodium falciparum is one of the leading asexual blood stage antigens being considered for inclusion in a malaria vaccine. The ability of this molecule to induce a protective immune response has been shown to be dependent upon a conformation stabilized by disulfide bonds. In this study we have utilized the reversed-phase high performance liquid chromatography of...

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PMID: 8910611
DOI: 10.1074/jbc.271.46.29446

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The Disulfide Bond Structure of Plasmodium Apical Membrane Antigen-1PMID 8910611Read ↗

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Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes.Semantic proximity Read ↗

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The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory AntibodySemantic proximity Read ↗

Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen.Semantic proximity Read ↗

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