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Article

Structure of AMA1 from <i>Plasmodium falciparum</i> reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket

29 Aug 2005

Abstract excerpt

Apical membrane antigen 1 (AMA1) is a leading malaria vaccine candidate that possesses polymorphisms that may pose a problem for a vaccine based on this antigen. Knowledge of the distribution of the polymorphic sites on the surface of AMA1 is necessary to obtain a detailed understanding of their significance for vaccine development. For this reason we have sought to determine the three-dimensional structure of...

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PMID: 16129835
DOI: 10.1073/pnas.0501808102

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