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Article

An Inhibitory Antibody Blocks Interactions between Components of the Malarial Invasion Machinery

22 Jan 2009

Abstract excerpt

Host cell invasion by apicomplexan pathogens such as the malaria parasite Plasmodium spp. and Toxoplasma gondii involves discharge of proteins from secretory organelles called micronemes and rhoptries. In Toxoplasma a protein complex comprising the microneme apical membrane antigen 1 (AMA1), two rhoptry neck proteins, and a protein called Ts4705, localises to the moving junction, a region of close apposition...

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PMID: 19165323
DOI: 10.1371/journal.ppat.1000273

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