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Intramembrane Cleavage of AMA1 Triggers <i>Toxoplasma</i> to Switch from an Invasive to a Replicative Mode

23 Dec 2010

Abstract excerpt

Apicomplexan parasites invade host cells and immediately initiate cell division. The extracellular parasite discharges transmembrane proteins onto its surface to mediate motility and invasion. These are shed by intramembrane cleavage, a process associated with invasion but otherwise poorly understood. Functional analysis of Toxoplasma rhomboid 4, a surface intramembrane protease, by conditional overexpression of...

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PMID: 21205639
DOI: 10.1126/science.1199284

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