Article
Unraveling features of the natural MHC class II peptidome of skin-migrated dendritic cells.
International immunology - 1 Jan 2012
Muixí Laia, Contreras Vanessa, Collado Javier A, Alexandre Yannick, Ballingall Keith, Bonneau Michel, Jaraquemada Dolores, Schwartz-Cornil Isabelle
Abstract excerpt
Dendritic cells (DCs) migrating from peripheral tissues at steady state are considered the most efficient antigen-presenting cells (APCs) involved in the induction of peripheral T-cell tolerance via self-antigen presentation on MHC class II molecules. However, difficulties in obtaining sufficient numbers of such DCs have precluded previous analyses of their natural MHC class II peptidome in laboratory animals or...
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